According to the UN Convention on the Rights of Persons with Disabilities which include persons with mental defects, it is necessary To ensure the realization of all human rights for this category of persons. The Republic of Croatia and the implementation of EU legislation must persist in applying the principle of reasonable accommodation of this category of employees, which is reflected in the support for life and work in the community, particularly in the area of work through the examples of good practice. The goal is to create guidelines that would be the foundation of greater involvement of people with mental disorders into the labor market and the protection of such persons in the workplace. Today, almost all people are exposed to stress that negatively affects mental health. There are campaigns against causing stress in the workplace, to raise awareness in the fight for the so-called. "Healthy Workplaces". Campaigns gather various experts, from those involved in the protection of health, safety at work as well as those involved in the organization of recreational activities. Stress is an inevitable part of human activity. The factors that cause it are called stressors. Stress can cause the development of serious illnesses (anxiety, depression, reduced functioning of the immune system). When it comes to the workplace, and today it is often the case, workers are insecure, which is an indicator of stress. Sudden changes in the workplace, necesity of performing additional tasks at home, burnout syndrome, insufficient holidays and low wages is what affects the mental health of workers. This leads to anxiety, concentration problems, constant fatigue, social isolation, bitterness and finally taking psychoactive substances. Work then becomes a heavy burden for worker. The goal is to raise awareness and the general public and especially among employers and employees about the importance of stress prevention.