Translationally related nearly identical molecules: 4-methoxyphenyl 4-O-[6-O-acetyl-2-azido-3-O-benzyl-2-deoxy-4-O-(fluoren-9-ylmethoxycarbonyl)-α-D-glucopyranosyl]-2-O-benzoyl-3-O-benzyl-6-O-chloroacetyl-β-D-glucopyranoside

被引：0

作者：

Gainsford, Graeme J. ^{[1
]}

Schwoerer, Ralf ^{[1
]}

Tyler, Peter C. ^{[1
]}

机构：

[1] Callaghan Innovat Res Ltd, Lower Hutt, New Zealand

来源：

ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS | 2013年 / 69卷

关键词：

HEPARAN-SULFATE; CRYSTAL-STRUCTURES; BETA-SECRETASE;

D O I：

10.1107/S010827011301367X

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The title compound, C59H56ClN3O16, is an important dissacharide precursor to novel therapeutics for the treatment of Alzheimer's disease. It crystallizes with two independent enantiomerically identical molecules in almost exactly the same orientation in the cell, being one half cell-edge apart. Apart from the conformation of a single benzyl group, the molecules are superimposable. They are bound efficiently using complementary C-H center dot center dot center dot O(carbonyl) hydrogen bonds, principally along the 'duplicating' axis. The absolute configurations were determined.

引用

页码：679 / U385

页数：27

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