Spatial working memory deficits in adolescents at clinical high risk for schizophrenia

被引：72
|
作者：
Smith, CW
Park, S
Cornblatt, B
机构：
[1] Vanderbilt Univ, Dept Psychol, Nashville, TN 37240 USA
[2] Hillside Hosp, N Shore Long Isl Jewish Hlth Syst, NSLIJHS, Glen Oaks, NY 11042 USA
来源：
SCHIZOPHRENIA RESEARCH | 2006年 / 81卷 / 2-3期
关键词：
schizophrenia; prodrome; high-risk adolescence; working memory; prefrontal function;
D O I：
10.1016/j.schres.2005.09.019
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Identifying endophenotypic markers is crucial to schizophrenia research for finding appropriate preventive strategies. Working memory (WM) deficit has been suggested as a marker for schizophrenia but its presence in adolescents at high risk is understudied. We piloted a test of spatial WM function in adolescents at clinical high risk (CHR) for schizophrenia and in age-and IQ-matched low-risk control subjects. CHR adolescents showed deficits in spatial WM compared with controls but showed intact performance on a non-WM-demanding spatial control task. Although based on a small pilot study, the results strongly suggest that WM deficit may be a risk factor for psychosis. (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码：211 / 215
页数：5
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