High levels of antibodies to Plasmodium falciparum liver stage antigen-1 in naturally infected individuals in Myanmar

被引：2
|
作者：
Lee, Hyeong-Woo [1 ]
Moon, Sung-Ung [1 ]
Kim, Yeon-Joo [1 ]
Cho, Shin-Hyeong [1 ]
Lin, Khin [2 ]
Na, Byoung-Kuk [3 ,4 ]
Kim, Tong-Soo [1 ,5 ,6 ]
机构：
[1] Korea Ctr Dis Control & Prevent, Natl Inst Hlth, Div Malaria & Parasit Dis, Seoul 122701, South Korea
[2] Dept Hlth, Vector Borne Dis Control Project, Mandalay, Myanmar
[3] Gyeongsang Natl Univ, Coll Med, Inst Hlth Sci, Jinju 660751, South Korea
[4] Gyeongsang Natl Univ, Coll Med, Dept Parasitol, Jinju 660751, South Korea
[5] Inha Univ, Coll Med, Dept Parasitol, Inchon 400712, South Korea
[6] Inha Univ, Coll Med, Inha Res Inst Med Sci, Inchon 400712, South Korea
来源：
KOREAN JOURNAL OF PARASITOLOGY | 2008年 / 46卷 / 03期
关键词：
Plasmodium falciparum; liver stage malaria antigen; recombinant protein; antibody response; Myanmar;
D O I：
10.3347/kjp.2008.46.3.195
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Plasmodium falciparum liver stage antigen-1 (PfLSA-1) is one of the few antigens expressed exclusively in liver stage parasites. In this study, we evaluated the antibody responses against recombinant PfLSA-1 in naturally infected individuals in Myanmar. High levels of antibody responses (70.7%) were detected in 82 serum samples from 116 infected individuals, and IgG responses to PfLSA-1 principally composed of responses of IgG1 and IgG3 subclasses. These results show that PfLSA-1 elicits effective antibody responses in individuals infected with P. falciparum, and thus it could be not only an attractive candidate protein for vaccine development, but also a useful antigen for serodiagnosis of the infection.
引用
收藏
页码：195 / 198
页数：4
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