In vitro activities of antifungal drugs against a large collection ofTrichophyton tonsuransisolated from wrestlers

Background Trichophyton tonsuransis the most common agent causing tinea gladiatorum in wrestlers, and limited data on susceptibility profiles ofTrichophyton tonsuransare available. Objectives We aimed to assess the in vitro activity of the common antifungal drug against a large collection ofT tonsurans. Materials/Methods The in vitro activities to eight common antifungal drugs (sertaconazole, itraconazole, clotrimazole, fluconazole, butenafine, tolnaftate, terbinafine and griseofulvin) against 128 clinical isolates ofT tonsuransstrains, obtained from wrestlers with dermatophytosis, were performed according to CLSI M38-A2 broth microdilution document. Results The geometric mean minimum inhibitory concentration was the lowest for tolnaftate (0.022 mu g/mL), followed by itraconazole (0.026 mu g/mL), terbinafine (0.033 mu g/mL), butenafine (0.088 mu g/mL), griseofulvin (0.566 mu g/mL), sertaconazole (2.875 mu g/mL), clotrimazole (3.419 mu g/mL) and fluconazole (12.540 mu g/mL). Conclusions Evaluation of antifungal susceptibility of dermatophytes showed that tolnaftate and itraconazole were the most effective drugs againstT tonsuransand fluconazole had the least effect.