Synthesis and Characterization of Hyaluronic Acid Modified Colloidal Mesoporous Silica Nanoparticles

被引：3
|
作者：
Zhang, Wenbiao [1 ,2 ,3 ]
Wang, Yu [1 ,2 ,3 ]
Li, Zhen [1 ,2 ,3 ]
Wang, Wanxia [1 ,2 ,3 ]
Sun, Honghao [1 ,2 ,3 ]
Liu, Mingxing [1 ,2 ,3 ]
机构：
[1] Hubei Univ Technol, Minist Educ, Key Lab Fermentat Engn, Wuhan 430068, Hubei, Peoples R China
[2] Hubei Univ Technol, Hubei Prov Cooperat Innovat Ctr Ind Fermentat, Wuhan 430068, Hubei, Peoples R China
[3] Hubei Univ Technol, Hubei Key Lab Ind Microbiol, Wuhan 430068, Hubei, Peoples R China
来源：
5TH ANNUAL INTERNATIONAL CONFERENCE ON MATERIAL SCIENCE AND ENGINEERING (ICMSE2017) | 2018年 / 275卷
基金：
中国国家自然科学基金;
关键词：
D O I：
10.1088/1757-899X/275/1/012009
中图分类号：
TH [机械、仪表工业];
学科分类号：
0802 ;
摘要：
The colloidal mesoporous silica nanoparticles functionalized with hyaluronic acid (CMS-HA) were successfully synthesized by grafting hyaluronic acid onto the external surface of the amino-functionalized mesoporous silica nanoparticles (CMS-NH2). Moreover, the paticle properties of CMS-HA were characterized by fourier transform infrared spectroscopy (FT-IR), dynamic light scattering (DLS) and transmission electron microscopy (TEM). The nanomaterials were negatively charged and had a relatively uniform spherical morphology with about 100 nm in diameter, which could make it more compatible with blood. So the results suggested that the CMS-HA might be a critical nanomaterial for applying in target drug delivery system.
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页数：4
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