Magnetic hydrogel nanocomposites for remote controlled pulsatile drug release

被引：400

作者：

Satarkar, Nitin S. ^{[1
]}

Hilt, J. Zach ^{[1
]}

机构：

[1] Univ Kentucky, Dept Chem & Mat Engn, Lexington, KY 40506 USA

来源：

JOURNAL OF CONTROLLED RELEASE | 2008年 / 130卷 / 03期

基金：

美国国家科学基金会;

关键词：

Hydrogel; Magnetic; Composite; Remote control; Drug delivery;

D O I：

10.1016/j.jconrel.2008.06.008

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Hydrogel nanocomposites are novel macromolecular biomaterials that promise to impact various applications in medical and pharmaceutical fields. In this paper, magnetic nanocomposites of temperature responsive hydrogels were used to illustrate remote controlled (RC) drug delivery. A high frequency alternating magnetic field (AMF) was used to trigger the on-demand pulsatile drug release from the nanocomposites. Nanocomposites were synthesized by incorporation of superparamagnetic Fe3O4 particles in negative temperature sensitive poly (N-isopropylacrylamide) hydrogels. Pulses of AMF were applied to the nanocomposites and the kinetics of collapse and recovery were characterized. Application of AMF resulted in uniform heating within the nanocomposites leading to accelerated collapse and squeezing out large amounts of imbibed drug (release at a faster rate). Remote controlled pulsatile drug release was characterized for different drugs as well as for different ON-OFF durations of the AMF. (C) 2008 Elsevier B.V. All rights reserved

引用

页码：246 / 251

页数：6

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