Functional Magnetic Resonance Imaging (fMRI) with Auditory Stimulation in Songbirds

被引:4
|
作者
Van Ruijssevelt, Lisbeth [1 ]
De Groof, Geert [1 ]
Van der Kant, Anne [1 ]
Poirier, Colline [1 ]
Van Audekerke, Johan [1 ]
Verhoye, Marleen [1 ]
Van der Linden, Annemie [1 ]
机构
[1] Univ Antwerp, Bioimaging Lab, Antwerp, Belgium
来源
基金
比利时弗兰德研究基金会;
关键词
Behavior; Issue; 76; Neuroscience; Neurobiology; Molecular Biology; Medicine; Biophysics; Physiology; Anatomy; Functional MRI; fMRI; Magnetic Resonance Imaging; MRI; blood oxygenation level dependent fMRI; BOLD fMRI; Brain; Songbird; zebra finches; Taeniopygia guttata; Auditory Stimulation; stimuli; animal model; imaging; SPIN-ECHO FMRI; BOLD FMRI; GRADIENT-ECHO; MRI; BRAIN; SONG; FOREBRAIN; RESPONSES;
D O I
10.3791/4369
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The neurobiology of birdsong, as a model for human speech, is a pronounced area of research in behavioral neuroscience. Whereas electrophysiology and molecular approaches allow the investigation of either different stimuli on few neurons, or one stimulus in large parts of the brain, blood oxygenation level dependent (BOLD) functional Magnetic Resonance Imaging (fMRI) allows combining both advantages, i.e. compare the neural activation induced by different stimuli in the entire brain at once. fMRI in songbirds is challenging because of the small size of their brains and because their bones and especially their skull comprise numerous air cavities, inducing important susceptibility artifacts. Gradient-echo (GE) BOLD fMRI has been successfully applied to songbirds (1-5) (for a review, see (6)). These studies focused on the primary and secondary auditory brain areas, which are regions free of susceptibility artifacts. However, because processes of interest may occur beyond these regions, whole brain BOLD fMRI is required using an MRI sequence less susceptible to these artifacts. This can be achieved by using spin-echo (SE) BOLD fMRI (7,8). In this article, we describe how to use this technique in zebra finches (Taeniopygia guttata), which are small songbirds with a bodyweight of 15-25 g extensively studied in behavioral neurosciences of birdsong. The main topic of fMRI studies on songbirds is song perception and song learning. The auditory nature of the stimuli combined with the weak BOLD sensitivity of SE (compared to GE) based fMRI sequences makes the implementation of this technique very challenging.
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页数:9
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