PIK3CA Mutations in Advanced Ovarian Carcinomas

被引：104

作者：

Wang, Yun ^{[1
,2
,5
]}

Helland, Aslaug ^{[2
,3
]}

Holm, Ruth ^{[4
]}

Kristensen, Gunnar B. ^{[1
]}

Borresen-Dale, Anne-Lise ^{[2
,5
]}

机构：

[1] Norwegian Radium Hosp, Dept Gynecol Oncol, N-0310 Oslo, Norway

[2] Norwegian Radium Hosp, Dept Genet, N-0310 Oslo, Norway

[3] Norwegian Radium Hosp, Dept Oncol, N-0310 Oslo, Norway

[4] Norwegian Radium Hosp, Dept Pathol, N-0310 Oslo, Norway

[5] Univ Oslo, Fac Div Radium Hosp, Oslo, Norway

来源：

HUMAN MUTATION | 2005年 / 25卷 / 03期

关键词：

PIK3CA gene; PIK3CA mutation; ovarian carcinoma;

D O I：

10.1002/humu.9316

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

PIK3CA belongs to the phosphatidylinositol 3-kinases (PI3Ks) family, which play an important role in proliferation, adherence, transformation and cell survival through the PI3K/AKT signaling pathway. Somatic activating mutations of this gene have recently been detected in several types of cancers. In the present study, 109 advanced ovarian carcinomas were analyzed for PIK3CA mutations in exon 9 and exon 20 by direct sequencing. Activating missense mutations were observed in 4 of the 109 tumors in addition to one variant leading no change of the PIK3CA protein. Two of the cases with mutations were mucinous and clear cell tumors, suggesting that PIK3CA mutations are more common in these rare histological types. (C) 2005 Wiley-Liss, Inc.

引用

页数：5

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