Analysis of frusemide by application of hydrotropic solubilization phenomenon in solid dosage form

被引：0
|
作者：
Maheshwari, R. K. [1 ]
Pandey, S. P. [1 ]
Ramchandani, U. [1 ]
Gupta, H. M. [1 ]
机构：
[1] Shri GS Inst Technol & Sci, Dept Pharm, Indore 452003, Madhya Pradesh, India
来源：
ASIAN JOURNAL OF CHEMISTRY | 2008年 / 20卷 / 01期
关键词：
hydrotropic; frusemide; urea; sodium salicylate;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In the present investigation, frusemide has been selected as a poorly water-soluble model drug. There was more than 30-fold enhancement in aqueous solubility of frusemide by 2.0 M sodium salicylate (as compared to aqueous solubility). This hydrotropic agent was employed to solubilize drug from the fine powder of tablet formulations. The hydrotropic agent and the additive used in formulation did not interfere in analysis. Proposed method is new, simple, accurate and reproducible. Statistical data proved the accuracy, reproducibility and the precision of the method.
引用
收藏
页码：277 / 281
页数：5
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