Epigenetic Control of Reprogramming and Transdifferentiation by Histone Modifications

被引：26
|
作者：
Qin, Hua [1 ]
Zhao, Andong [1 ]
Zhang, Cuiping [2 ]
Fu, Xiaobing [2 ]
机构：
[1] Tianjin Med Univ, Tianjin 300070, Peoples R China
[2] Peoples Liberat Army Gen Hosp, Hosp Affiliated 1, Key Lab Wound Repair & Regenerat PLA, 51 Fu Cheng Rd, Beijing, Peoples R China
来源：
STEM CELL REVIEWS AND REPORTS | 2016年 / 12卷 / 06期
关键词：
Somatic cells; iPSCs; Reprogramming; Transdifferentiation; Histone modifications; Epigenetic; Cell fate conversion; PLURIPOTENT STEM-CELLS; PIONEER TRANSCRIPTION FACTORS; SMALL-MOLECULE; MOUSE FIBROBLASTS; SOMATIC-CELLS; DIRECT CONVERSION; PROGENITOR CELLS; NEURONAL CELLS; EXPRESSION; GENERATION;
D O I：
10.1007/s12015-016-9682-4
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Somatic cells can be reprogrammed to pluripotent stem cells or transdifferentiate to another lineage cell type. Much efforts have been made to unravel the epigenetic mechanisms underlying the cell fate conversion. Histone modifications as the major epigenetic regulator are implicated in various aspects of reprogramming and transdifferentiation. Here, we discuss the roles of histone modifications on reprogramming and transdifferentiation and hopefully provide new insights into induction and promotion of the cell fate conversion by modulating histone modifications.
引用
收藏
页码：708 / 720
页数：13
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