Alcoholic and non-alcoholic steatohepatitis: Who is affected and what can we do for them?

被引：5
|
作者：
Gallego-Duran, Rocio
Ampuero, Javier
Funuyet, Jorge
Romero-Gomez, Manuel [1 ]
机构：
[1] Univ Seville, Unidad Med Quirurg Enfermedades Digest, Seville, Spain
来源：
GASTROENTEROLOGIA Y HEPATOLOGIA | 2013年 / 36卷 / 09期
关键词：
Alcoholic steatohepatitis; Non-alcoholic steatohepatitis; Noninvasive diagnosis; Pathogenic mechanisms of steatohepatitis; Therapeutic management; FATTY LIVER-DISEASE; PLACEBO-CONTROLLED TRIAL; VITAMIN-E; NONINVASIVE ASSESSMENT; INCREASED EXPRESSION; HEPATIC STEATOSIS; NATURAL-HISTORY; DIAGNOSIS; PIOGLITAZONE; METFORMIN;
D O I：
10.1016/j.gastrohep.2013.06.005
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
The most common causes of steatohepatitis are alcohol intake and metabolic disorders. Several methods based on biochemical determinations (carbohydrate deficient transferrin) and questionnaires (AUDIT, CAGE, MALE) are useful for detecting surreptitious alcohol intake. Although new non-invasive methods are under development, based both on lipidomics (Owl-Liver (R)) and on biochemical determinations and anthropometric parameters (NAFLD Fibrosis score) or imaging methods (DeMILI NASH-MRi (R)), none has been proposed as definitive and the gold standard continues to be liver biopsy. The pathogenesis of alcoholic and non-alcoholic steatohepatitis shares some elements such as insulin resistance, cytochrome CYP2E1-mediated oxidative stress, adiponutrin and its PNPLA3 gene, and the microbiota. The first-line treatment consists of lifestyle changes, including giving up alcohol, diet and exercise. (C) 2013 Elsevier Espana, S.L. and AEEH y AEG. All rights reserved.
引用
收藏
页码：587 / 596
页数：10
相关论文
共 50 条
  • [1] What diet can we offer to patients with non-alcoholic steatohepatitis?
    Andre-Dumont, Stephanie, I
    Lanthier, Nicolas
    [J]. NUTRITION CLINIQUE ET METABOLISME, 2022, 36 (01): : 12 - 20
  • [2] Non-Alcoholic Steatohepatitis: What Can We Learn from Animal Models?
    Almonacid-Urrego, C. C.
    Sanchez-Campos, S.
    Tunon, M. J.
    Gonzalez-Gallego, J.
    [J]. CURRENT MEDICINAL CHEMISTRY, 2012, 19 (09) : 1389 - 1404
  • [3] Alcoholic and non-alcoholic steatohepatitis
    Neuman, Manuela G.
    French, Samuel W.
    French, Barbara A.
    Seitz, Helmut K.
    Cohen, Lawrence B.
    Mueller, Sebastian
    Osna, Natalia A.
    Kharbanda, Kusum K.
    Seth, Devanshi
    Bautista, Abraham
    Thompson, Kyle J.
    McKillop, Iain H.
    Kirpich, Irina A.
    McClain, Craig J.
    Bataller, Ramon
    Nanau, Radu M.
    Voiculescu, Mihai
    Opris, Mihai
    Shen, Hong
    Tillman, Brittany
    Li, Jun
    Liu, Hui
    Thomes, Paul G.
    Ganesan, Murali
    Malnick, Steve
    [J]. EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2014, 97 (03) : 492 - 510
  • [4] Alcoholic and non-alcoholic steatohepatitis
    不详
    [J]. PATHOLOGY RESEARCH AND PRACTICE, 2005, 201 (03) : 266 - 266
  • [5] Global epidemiology of non-alcoholic fatty liver disease/non-alcoholic steatohepatitis: What we need in the future
    Araujo, Ana Ruth
    Rosso, Natalia
    Bedogni, Giorgio
    Tiribelli, Claudio
    Bellentani, Stefano
    [J]. LIVER INTERNATIONAL, 2018, 38 : 47 - 51
  • [6] Treatment of alcoholic and non-alcoholic steatohepatitis
    Stremmel, W
    Blechacz, B
    Herrmann, T
    Rost, D
    Mueller, S
    [J]. INTERNIST, 2001, 42 (12): : 1641 - +
  • [7] Do we need a histological score to diagnose non-alcoholic steatohepatitis?
    Wong, V. W. -S.
    Chan, H. L. -Y.
    [J]. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2011, 34 (04) : 494 - 495
  • [8] Combined alcoholic and non-alcoholic steatohepatitis
    Wandji, Line Carolle Ntandja
    Gnemmi, Viviane
    Mathurin, Philippe
    Louvet, Alexandre
    [J]. JHEP REPORTS, 2020, 2 (03)
  • [9] Non-alcoholic Steatohepatitis (NASH) and alcoholic Steatohepatitis (ASH)
    Roeb, Elke
    [J]. DRUG RESEARCH, 2021, 71 : S16 - S18
  • [10] Non-alcoholic steatohepatitis
    Dancygier, H
    [J]. DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT, 2001, 126 (33) : 930 - 930
12345