Liquid-liquid chromatography in enantioseparations

被引：12
|
作者：
Tong, Shengqiang [1 ]
机构：
[1] Zhejiang Univ Technol, Coll Pharmaceut Sci, Chaowang Rd 18,Chaohui 6 Dist, Hangzhou 310032, Peoples R China
来源：
JOURNAL OF CHROMATOGRAPHY A | 2020年 / 1626卷
基金：
中国国家自然科学基金;
关键词：
Chiral selectors; Enantioseparation; Liquid-liquid chromatography; Review; COUNTER-CURRENT CHROMATOGRAPHY; MULTIPLE CHIRAL CENTERS; CENTRIFUGAL PARTITION CHROMATOGRAPHY; HYDROXYPROPYL-BETA-CYCLODEXTRIN; ACID ENANTIOMERS; PREPARATIVE ENANTIOSEPARATION; PHENYLSUCCINIC ACID; SEPARATION; RESOLUTION; DERIVATIVES;
D O I：
10.1016/j.chroma.2020.461345
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Modern liquid-liquid chromatography mainly refers to the following two kinds of chromatographic apparatuses: countercurrent chromatography based on hydrodynamic equilibrium systems and centrifugal partition chromatography based on hydrostatic equilibrium systems. In this paper, the recent advancements in enantioseparations by liquid-liquid chromatography, including the separation mechanism, chiral selector, two-phase solvent system, methods to improve the peak resolution and recent applications, are reviewed. The future outlook for liquid-liquid chromatography in enantioseparations is also proposed. (C) 2020 Elsevier B.V. All rights reserved.
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页数：14
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