Synthesis of conformationally constrained lysine analogues

被引：13

作者：

Ganorkar, Rakesh ^{[1
]}

Natarajan, Amarnath ^{[1
]}

Mamai, Ahmed ^{[1
]}

Madalengoitia, Jose S. ^{[1
]}

机构：

[1] Univ Vermont, Dept Chem, Burlington, VT 05405 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2006年 / 71卷 / 13期

关键词：

D O I：

10.1021/jo060210f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of two conformationally constrained lysine analogues is reported. The synthesis of the novel analogue 1 based on the 3-aza-bicyclo[3.1.0] hexane system is accomplished from the known tricycle 3 in eight steps. The synthesis of the analogue 2 is accomplished in eight steps from 4-hydroxy proline. Both analogues are synthesized appropriately protected for Fmoc/Boc solid-phase peptide synthesis.

引用

页码：5004 / 5007

页数：4

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