Folding of a three-helix bundle at the folding speed limit

被引：52
|
作者：
Wang, T [1 ]
Zhu, YJ [1 ]
Gai, F [1 ]
机构：
[1] Univ Penn, Dept Chem, Philadelphia, PA 19104 USA
来源：
JOURNAL OF PHYSICAL CHEMISTRY B | 2004年 / 108卷 / 12期
关键词：
D O I：
10.1021/jp049652q
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
We show in this Letter that a double mutant (K51/K39V) of 1prb(7-53), the GA module of an albumin binding domain, has a maximum folding rate constant of similar to1 (mus)(-1). This value is comparable to the estimated theoretical speed limit for protein folding. In addition, we found that the mean hydrophobicity of a given tertiary fold plays an important role in controlling its folding rate.
引用
收藏
页码：3694 / 3697
页数：4
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