The many faces of the anti-COVID immune response

被引：391

作者：

Vardhana, Santosha A. ^{[1
,2
,3
]}

Wolchok, Jedd D. ^{[3
,4
,5
,6
,7
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Canc Biol & Genet Program, 1275 York Ave, New York, NY 10021 USA

[2] Mem Sloan Kettering Canc Ctr, Ctr Epigenet Res, 1275 York Ave, New York, NY 10021 USA

[3] Parker Inst Canc Immunotherapy, San Francisco, CA 94129 USA

[4] Mem Sloan Kettering Canc Ctr, Dept Med, Human Oncol Pathogenesis Program, 1275 York Ave, New York, NY 10021 USA

[5] Mem Sloan Kettering Canc Ctr, Ludwig Ctr, 1275 York Ave, New York, NY 10021 USA

[6] Weill Cornell Med, New York, NY USA

[7] Grad Sch Biomed Sci, New York, NY USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2020年 / 217卷 / 06期

关键词：

ACUTE RESPIRATORY SYNDROME; INFLUENZA-A H1N1; CD8; T-CELLS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; INTRAVENOUS N-ACETYLCYSTEINE; CLINICAL CHARACTERISTICS; ANTIVIRAL RESPONSES; CORONAVIRUS DISEASE; DOUBLE-BLIND; CYTOKINE;

D O I：

10.1084/jem.20200678

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The novel 2019 strain of coronavirus is a source of profound morbidity and mortality worldwide. Compared with recent viral outbreaks, COVID-19 infection has a relatively high mortality rate, the reasons for which are not entirely clear. Furthermore, treatment options for COVID-19 infection are currently limited. In this Perspective, we explore the contributions of the innate and adaptive immune systems to both viral control as well as toxicity during COVID-19 infections and offer suggestions to both understand and therapeutically modulate anti-COVID immunity.

引用

页数：10

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