Electrochemical array microsystem with integrated potentiostat

This paper presents a single-chip electrochemical array system with a high performance CMOS potentiostat suitable for the implementation of a fully integrated instrument-on-chip microsystem. The chip contains a highly sensitive, range-programmable, amperometric readout amplifier that supports cyclic voltammetry assay techniques. Through post-CMOS fabrication, the surface of the chip provides an Au counter electrode, an Ag/AgCI reference electrode, and 30 array of individually addressable Au working electrodes. The microsystem is configurable and implements self-correction techniques to provide an adaptive interface for variety of electrochemical and current-mode sensors. The chip supports amperometric output from 10pA to 10 mu A and provides good noise performance to achieve sub-pA resolution.