N-HYDROXYLATION OF 4-AMINOBIPHENYL BY CYP2E1 AND ASSOCIATED OXIDATIVE STRESS MAY INFLUENCE ITS TUMORIGENICITY IN MOUSE LIVER

被引：0
|
作者：
Wang, Shuang [1 ]
Sugamori, Kim S. [1 ]
Grant, Denis M. [1 ]
机构：
[1] Univ Toronto, Dept Pharmacol & Toxicol, Toronto, ON, Canada
来源：
DRUG METABOLISM REVIEWS | 2014年 / 45卷
关键词：
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
引用
收藏
页码：203 / 204
页数：2
相关论文
共 34 条
  • [1] N-Hydroxylation of 4-Aminobiphenyl by CYP2E1 Produces Oxidative Stress in a Mouse Model of Chemically Induced Liver Cancer
    Wang, Shuang
    Sugamori, Kim S.
    Tung, Aveline
    McPherson, J. Peter
    Grant, Denis M.
    TOXICOLOGICAL SCIENCES, 2015, 144 (02) : 393 - 405
  • [2] N-hydroxylation of 4-aminobiphenyl (ABP) and associated oxidative stress may influence ABP carcinogenicity in the mouse liver
    Wang, Shuang
    Sugamori, Kim S.
    Grant, Denis M.
    CANCER RESEARCH, 2013, 73 (08)
  • [3] Relative Contributions of CYP1A2 and CYP2E1 to the Bioactivation and Clearance of 4-Aminobiphenyl in Adult Mice
    Wang, Shuang
    Bott, Debbie
    Tung, Aveline
    Sugamori, Kim S.
    Grant, Denis M.
    DRUG METABOLISM AND DISPOSITION, 2015, 43 (07) : 916 - 921
  • [4] Propolis alleviates 4-aminobiphenyl-induced oxidative DNA damage by inhibition of CYP2E1 expression in human liver cells
    Wahyuni, Eva Ari
    Chen, Chien Yi
    Wu, Huery Nuo
    Chien, Chih-Ching
    Chen, Ssu-Ching
    ENVIRONMENTAL TOXICOLOGY, 2021, 36 (08) : 1504 - 1513
  • [5] Nrf2 is increased by CYP2E1 in rodent liver and HepG2 cells and protects against oxidative stress caused by CYP2E1
    Gong, PF
    Cederbaum, AI
    HEPATOLOGY, 2006, 43 (01) : 144 - 153
  • [6] Reducing Oxidative Stress-Mediated Alcoholic Liver Injury by Multiplexed RNAi of Cyp2e1, Cyp4a10, and Cyp4a14
    Zhang, Qi
    Wu, Shuang
    Chen, Qiubing
    Zhang, Yahong
    Zhang, Cai
    Yin, Runting
    Ouyang, Zhen
    Wei, Yuan
    BIOMEDICINES, 2024, 12 (07)
  • [7] Amelioration of ethanol-induced oxidative stress and alcoholic liver disease by in vivo RNAi targeting Cyp2e1
    Yalan Wang
    Qiubing Chen
    Shuang Wu
    Xinyu Sun
    Runting Yin
    Zhen Ouyang
    Hao Yin
    Yuan Wei
    Acta Pharmaceutica Sinica B, 2023, (09) : 3906 - 3918
  • [8] Amelioration of ethanol-induced oxidative stress and alcoholic liver disease by in vivo RNAi targeting Cyp2e1
    Wang, Yalan
    Chen, Qiubing
    Wu, Shuang
    Sun, Xinyu
    Yin, Runting
    Ouyang, Zhen
    Yin, Hao
    Wei, Yuan
    ACTA PHARMACEUTICA SINICA B, 2023, 13 (09) : 3906 - 3918
  • [9] ATF4 deficiency protects hepatocytes from oxidative stress via inhibiting CYP2E1 expression
    Wang, Chunxia
    Li, Houkai
    Meng, Qingshu
    Du, Ying
    Xiao, Fei
    Zhang, Qian
    Yu, Junjie
    Li, Kai
    Chen, Shanghai
    Huang, Zhiying
    Liu, Bin
    Guo, Feifan
    JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2014, 18 (01) : 80 - 90
  • [10] Oxidative stress, glutathione, and CYP2E1 in 1,4-dioxane liver cytotoxicity and genotoxicity: insights from animal models
    Wang, Yewei
    Charkoftaki, Georgia
    Davidson, Emily A.
    Orlicky, David J.
    Tanguay, Robyn L.
    Thompson, David C.
    Vasiliou, Vasilis
    Chen, Ying
    CURRENT OPINION IN ENVIRONMENTAL SCIENCE & HEALTH, 2022, 29
1234