Regulation of intestinal cancer stem cells

被引：20
|
作者：
Ashley, Neil [1 ]
机构：
[1] Univ Oxford, John Radcliffe Hosp, Weatherall Inst Mol Med, Canc & Immunogenet Lab, Oxford OX3 9DS, England
来源：
CANCER LETTERS | 2013年 / 338卷 / 01期
关键词：
Stem cells; Colon; Wnt; Notch; BMP; Differentiation; Hypoxia; Regulation; Myofibroblasts; TUMOR-INITIATING CELLS; WNT SIGNALING PATHWAY; GROWTH-FACTOR-BETA; HUMAN SOLID TUMORS; WNT/BETA-CATENIN; EPITHELIAL-CELLS; SELF-RENEWAL; SUBEPITHELIAL MYOFIBROBLASTS; LINEAGE COMMITMENT; EXPRESSION PATTERN;
D O I：
10.1016/j.canlet.2012.04.016
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Colorectal tumours harbour a sub-population of cells with stem like properties termed 'cancer stem cells', which are believed to ultimately drive cancer growth. This review discusses recent advances in our understanding of both normal and cancer intestinal stem cells, with emphasis on similarities and differences. Specifically we discuss the role of the Wnt, Notch and BMP pathways and their roles in both stem cell proliferation and differentiation. Furthermore we discuss the emerging role of microRNA and the influence of environmental factors such as tumour associated myofibroblasts and hypoxia on cancer stem cell regulation. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：120 / 126
页数：7
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