New organoselenium compounds active against pathogenic bacteria, fungi and viruses

被引：67

作者：

Pietka-Ottlik, Magdalena ^{[1
]}

Wojtowicz-Mlociiowska, Halina ^{[1
]}

Kolodziejczyk, Katarzyna ^{[1
]}

Piasecki, Egbert ^{[2
]}

Mlochowski, Jacek ^{[1
]}

机构：

[1] Wroclaw Univ Technol, Fac Chem, Dept Organ Chem, PL-50370 Wroclaw, Poland

[2] Polish Acad Sci, Inst Immunol & Expt Therapy, PL-53114 Wroclaw, Poland

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2008年 / 56卷 / 10期

关键词：

benzisoselenazol-3(2II)-one; antiviral agent; antimicrobial agent; organoselenium compound; ebselen;

D O I：

10.1248/cpb.56.1423

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Different N-substituted benzisoselenazol-3(2H)-ones, analogues of ebselen were designed as new antiviral and antimicrobial agents. We report their synthesis, chemical properties as well as study on biological activity against broad spectrum of pathogenic microorganisms (Slaphylococcus aureus, Staphylococcus simulans, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Candida albicans, Aspergillus niger) and viruses (herpes simplex virus type 1 (HSV-1), encephalomyocarditis virus (EMCV), vesicular stomatitis virus (VSV)), ill vitro. Most of them exhibited high activity against viruses (HSV-1, EMCV) and grain-positive bacteria strains (S. aureus, S. simulans), while their activity against gram-negative bacteria strains (F. coli, P aerughlosa, K. pneumoniae) was substantially, lower. Sonic of tested compounds were active against yeast C albicans and filamentous fungus.A. niger.

引用

页码：1423 / 1427

页数：5

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