Beneficial effects of add-on raloxifene in schizophrenia A case report

被引:11
|
作者
Sharma, Eesha [1 ]
Raveendranathan, Dhanya [1 ]
Shivakumar, Venkataram [1 ]
Jayaram, Naveen [1 ]
Rao, Naren P. [1 ]
Venkatasubramanian, Ganesan [1 ]
机构
[1] Natl Inst Mental Hlth & Neurosci, Metab Clin Psychiat, Dept Psychiat, Bangalore 560029, Karnataka, India
关键词
Schizophrenia; Selective estrogen receptor modulators; Raloxifene; POSTMENOPAUSAL WOMEN;
D O I
10.1007/s00737-012-0259-1
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
The role of estrogens in schizophrenia has been proposed from the observation of schizophrenia occurring later and with symptom severity being lesser in women. Utility of estrogens in treatment of psychoses, though seen to be useful, comes with inherent risks of neoplasias, given its agonistic action on breast and endometrium. This risk can be overcome with use of selective estrogen receptor modulators, like raloxifene. Raloxifene has been used in schizophrenia, with improvement in symptoms and cognitive functions. We report the use of raloxifene as an adjunctive treatment, with risperidone, in treatment-resistant form of schizophrenia. The patient, a 29-year-old woman, over a 7-month follow-up period, showed significant improvement in socio-occupational functioning, with reduction in symptom severity.
引用
收藏
页码:147 / 148
页数:2
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