Effects of hypothermic and normothermic cardiopulmonary bypass on brain oxygenation

Background. In this study, we assessed the effects of normothermia and hypothermia during cardiopulmonary bypass (CPB) both on internal jugular venous oxygen saturation (SjvO(2)) and the regional cerebral oxygenation state (rSO(2)) estimated by near infrared spectroscopy (NIRS). Methods. Thirty patients scheduled for elective coronary artery bypass graft surgery (CABG) were randomly divided into two groups. Group 1 (n = 15) underwent surgery for normothermic (>35 degrees C) CPB, and group 2 (n 15) underwent surgery for hypothermic (30 degrees C) CPB, and alpha-stat regulation was applied. A 4.0-French fiberoptic oximetry oxygen saturation catheter was inserted into the right jugular bulb to continuously monitor the SjvO(2) value. To estimate the rSO(2) state, a spectrophotometer probe was attached to the mid-forehead. SjvO(2) and rSO(2) values were then collected simultaneously using a computer. Results. Neither the cerebral desaturation time (duration during SjvO(2) value below 50%), nor the ratio of the cerebral desaturation time to the total CPB time significantly differed (normothermic group: 18 +/- 6 min, 15 +/- 6%; hypothermic group: 17 +/- 6 min, 13 +/- 6%, respectively). The rSO(2) value in the normothermic group decreased during the CPB period compared with the pre-CFB period. The rSO(2) value in the hypothermic group did not change throughout the perioperative period. Conclusions. These findings suggest that near infrared spectroscopy might be sensitive enough to detect subtle changes in regional cerebral oxygenation. (C) 1999 by The Society of Thoracic Surgeons.