Endothelial progenitor cells in atherosclerosis

被引：101

作者：

Du, Fuyong ^{[1
,2
]}

Zhou, Jun ^{[1
,2
]}

Gong, Ren ^{[1
,2
]}

Huang, Xiao ^{[1
,2
]}

Pansuria, Meghana ^{[1
,2
]}

Virtue, Anthony ^{[1
,2
]}

Li, Xinyuan ^{[1
,2
]}

Wang, Hong ^{[1
,2
,3
]}

Yang, Xiao-Feng ^{[1
,2
]}

机构：

[1] Temple Univ, Sch Med, Dept Pharmacol, Philadelphia, PA 19140 USA

[2] Temple Univ, Sch Med, Cardiovasc Res Ctr, Philadelphia, PA 19140 USA

[3] Temple Univ, Sch Med, Thrombosis Res Ctr, Philadelphia, PA 19140 USA

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2012年 / 17卷

基金：

美国国家卫生研究院;

关键词：

Endothelial progenitor cells; Atherosclerosis; Inflammation; Review; LIPOPROTEIN INDUCES APOPTOSIS; NITRIC-OXIDE SYNTHASE; MARROW-DERIVED CELLS; SMOOTH-MUSCLE-CELLS; HUMAN CD34(+) CELLS; C-REACTIVE PROTEIN; BONE-MARROW; PERIPHERAL-BLOOD; IN-VITRO; EX-VIVO;

D O I：

10.2741/4055

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Endothelial progenitor cells (EPCs) are involved in the maintenance of endothelial homoeostasis and in the process of new vessel formation. Experimental and clinical studies have shown that atherosclerosis is associated with reduced numbers and dysfunction of EPCs; and that medications alone are able to partially reverse the impairment of EPCs in patients with atherosclerosis. Therefore, novel EPC-based therapies may provide enhancement in restoring EPCs' population and improvement of vascular function. Here, for a better understanding of the molecular mechanisms underlying EPC impairment in atherosclerosis, we provide a comprehensive overview on EPC characteristics, phenotypes, and the signaling pathways underlying EPC impairment in atherosclerosis.

引用

页码：2327 / 2349

页数：23

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