Structure of the GluR2 ligand-binding core reveals possible mechanism for receptor desensitization

被引:0
|
作者
Sun, Y
Horning, M
Olson, R
Mayer, ML
Gouaux, E
机构
[1] Columbia Univ, Howard Hughes Med Inst, New York, NY 10032 USA
[2] NIH, Bethesda, MD 20892 USA
关键词
D O I
暂无
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
1238
引用
收藏
页码:256A / 256A
页数:1
相关论文
共 50 条
  • [1] Action of agonists and antagonists on the AMPA GluR2 receptor ligand binding core
    Gouaux, E
    Armstrong, N
    Jin, RS
    [J]. JOURNAL OF GENERAL PHYSIOLOGY, 2000, 116 (01): : 5A - 5A
  • [2] Molecular dynamics simulations of the ligand-binding domain of the ionotropic glutamate receptor GluR2
    Arinaminpathy, Y
    Sansom, MSP
    Biggin, PC
    [J]. BIOPHYSICAL JOURNAL, 2002, 82 (02) : 676 - 683
  • [3] Three-dimensional structure of the ligand-binding core of GluR2 in complex with the agonist (S)-ATPA:: Implications for receptor subunit selectivity
    Lunn, ML
    Hogner, A
    Stensbol, TB
    Gouaux, E
    Egebjerg, J
    Kastrup, JS
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2003, 46 (05) : 872 - 875
  • [4] Modeling of peptides connecting the ligand-binding and transmembrane domains in the GluR2 glutamate receptor
    Speranskiy, K.
    Kurnikova, M. G.
    [J]. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2009, 76 (02) : 271 - 280
  • [5] Structural basis for AMPA receptor activation and ligand selectivity: Crystal structures of five agonist complexes with the GluR2 ligand-binding core
    Hogner, A
    Kastrup, JS
    Jin, R
    Liljefors, T
    Mayer, ML
    Egebjerg, J
    Larsen, IK
    Gouaux, E
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 2002, 322 (01) : 93 - 109
  • [6] Energy Transfer Ligands of the GluR2 Ligand Binding Core
    Petrik, Amy F.
    Strub, Marie-Paule
    Lee, Jennifer C.
    [J]. BIOCHEMISTRY, 2010, 49 (09) : 2051 - 2057
  • [7] Tyr702 is an important determinant of agonist binding and domain closure of the ligand-binding core of GluR2
    Frandsen, A
    Pickering, DS
    Vestergaard, B
    Kasper, C
    Nielsen, BB
    Greenwood, JR
    Campiani, G
    Fattorusso, C
    Gajhede, M
    Schousboe, A
    Kastrup, JS
    [J]. MOLECULAR PHARMACOLOGY, 2005, 67 (03) : 703 - 713
  • [8] The structure of a mixed GluR2 ligand-binding core dimer in complex with (S)-glutamate and the antagonist (S)-NS1209
    Kasper, C
    Pickering, DS
    Mirza, O
    Olsen, L
    Kristensen, AS
    Greenwood, JR
    Liljefors, T
    Schousboe, A
    Wätjen, F
    Gajhede, M
    Sigurskjold, BW
    Kastrup, JS
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 2006, 357 (04) : 1184 - 1201
  • [9] Chemistry and conformation of the ligand-binding domain of GluR2 subtype of glutamate receptors
    Cheng, Q
    Jayaraman, V
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (25) : 26346 - 26350
  • [10] Exploring the GluR2 ligand-binding core in complex with the bicyclical AMPA analogue (S)-4-AHCP
    Nielsen, BB
    Pickering, DS
    Greenwood, JR
    Brehm, L
    Gajhede, M
    Schousboe, A
    Kastrup, JS
    [J]. FEBS JOURNAL, 2005, 272 (07) : 1639 - 1648