Ehlers-Danlos syndrome;
Down syndrome;
Gait analysis;
Ligament laxity;
JOINT;
INDIVIDUALS;
D O I:
10.1016/j.ridd.2012.03.016
中图分类号:
G76 [特殊教育];
学科分类号:
040109 ;
摘要:
People suffering from Ehlers-Danlos syndrome (EDS) hypermobility type present a severe ligament laxity that results in difficulties in muscle force transmission. The same condition is present in people suffering from Down syndrome (DS) even if their clumsy movements are due to cerebral and cognitive impairments. The aim of this study was to quantify the gait patterns of subjects with EDS and with DS using Gait Analysis (GA). We quantified the gait strategy in 12 EDS individuals and in 16 participants with DS. Both pathological groups were compared to 20 age-matched healthy controls in terms of kinematics and kinetics. Results showed that DS individuals are characterized by a more compromised gait pattern than EDS participants, even if both groups are characterized by joint hypermobility. All the patients showed significant decreased of ankle stiffness probably due to congenital hypotonia and ligament laxity, while different values of hip stiffness. These findings help to elucidate the complex biomechanical changes due to joint hypermobility and may have a major role in the multidimensional evaluation and tailored management of these patients. (C) 2012 Elsevier Ltd. All rights reserved.
机构:
Advocate Childrens Hosp, Clin Genet, Park Ridge, IL USAAdvocate Childrens Hosp, Clin Genet, Park Ridge, IL USA
Tinkle, Brad
Castori, Marco
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机构:Advocate Childrens Hosp, Clin Genet, Park Ridge, IL USA
Castori, Marco
Berglund, Britta
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机构:
Uppsala Univ, Nursing Res, Uppsala, SwedenAdvocate Childrens Hosp, Clin Genet, Park Ridge, IL USA
Berglund, Britta
Cohen, Helen
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机构:
Royal Natl Orthopaed Hosp, Dept Rheumatol, Brockley Hill, Stanmore, Middx, EnglandAdvocate Childrens Hosp, Clin Genet, Park Ridge, IL USA
Cohen, Helen
Grahame, Rodney
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机构:
UCL, Ctr Rheumatol, London, England
Hosp St John & St Elizabeth, Hypermobil Unit, London, EnglandAdvocate Childrens Hosp, Clin Genet, Park Ridge, IL USA
Grahame, Rodney
Kazkaz, Hanadi
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机构:
Univ Coll Hosp, Rheumatol Dept, London, EnglandAdvocate Childrens Hosp, Clin Genet, Park Ridge, IL USA
Kazkaz, Hanadi
Levy, Howard
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机构:
Johns Hopkins Univ, Baltimore, MD 21218 USAAdvocate Childrens Hosp, Clin Genet, Park Ridge, IL USA
机构:
Johns Hopkins Univ Hosp, Div Cardiol, Baltimore, MD 21287 USAJohns Hopkins Univ Hosp, Div Cardiol, Baltimore, MD 21287 USA
Murray, Brittney
Yashar, Beverly M.
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机构:
Univ Michigan, Sch Med, Dept Human Genet, Ann Arbor, MI USAJohns Hopkins Univ Hosp, Div Cardiol, Baltimore, MD 21287 USA
Yashar, Beverly M.
Uhlmann, Wendy R.
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机构:
Univ Michigan, Sch Med, Dept Human Genet, Ann Arbor, MI USA
Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USAJohns Hopkins Univ Hosp, Div Cardiol, Baltimore, MD 21287 USA
Uhlmann, Wendy R.
Clauw, Daniel J.
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机构:
Univ Michigan Chron Pain & Fatigue Res, Dept Anesthesiol, Ann Arbor, MI USA
Univ Michigan Chron Pain & Fatigue Res, Dept Med Rheumatol, Ann Arbor, MI USA
Univ Michigan Chron Pain & Fatigue Res, Dept Psychiat, Ann Arbor, MI USAJohns Hopkins Univ Hosp, Div Cardiol, Baltimore, MD 21287 USA
Clauw, Daniel J.
Petty, Elizabeth M.
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机构:
Univ Wisconsin, Dept Pediat, Sch Med & Publ Hlth, Madison, WI USAJohns Hopkins Univ Hosp, Div Cardiol, Baltimore, MD 21287 USA