Probable Molecular Mechanism of Remdesivir for the Treatment of COVID-19: Need to Know More

被引：90
|
作者：
Saha, Abinit [1 ]
Sharma, Ashish Ranjan [2 ]
Bhattacharya, Manojit [3 ]
Sharma, Garima [4 ]
Lee, Sang-Soo [2 ]
Chakraborty, Chiranjib [1 ]
机构：
[1] Adamas Univ, Sch Life Sci & Biotechnol, Dept Biotechnol, Barasat Barrackpore Rd, Kolkata 700126, W Bengal, India
[2] Hallym Univ, Chuncheon Sacred Heart Hosp, Inst Skeletal Aging & Orthoped Surg, Chuncheon Si, Gangwon Do, South Korea
[3] Fakir Mohan Univ, Dept Zool, VyasaVihar, Balasore, Odisha, India
[4] Kangwon Natl Univ, Neuropsychopharmacol & Toxicol Program, Coll Pharm, Gangwon Do, South Korea
来源：
ARCHIVES OF MEDICAL RESEARCH | 2020年 / 51卷 / 06期
基金：
新加坡国家研究基金会;
关键词：
SARS-CoV-2; Remdesivir; COVID-19; Therapeutic molecule; GS-5734; EBOLA;
D O I：
10.1016/j.arcmed.2020.05.001
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
COVID-19 is now pandemic throughout the world. Scientist, doctors are searching for effective therapy of this diseases. The remdesivir, an antiviral drug, is appeared as 'molecule of hope' for the treatment of this disease. USFDA gave emergency approval to this drug for the treatment of COVID-19. The molecular mechanism is unknown. In this pa per, we tried to describe the probable molecular mechanism of remdesivir to inhibit the RNA synthesis of SARS-CoV-2. However, more detail mechanism is needed to understand mechanism of action of remdesivir. (c) 2020 IMSS. Published by Elsevier Inc.
引用
收藏
页码：585 / 586
页数：2
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