Preparation and in vitro percutaneous penetration of simvastatin ethosome gel

被引：6
|
作者：
An, Keyao [1 ]
Sun, Yong [1 ]
Wu, Yan [1 ,2 ]
Yuan, Haicheng [3 ]
Cui, Zhaoyuan [1 ]
Xu, Lisa [1 ]
机构：
[1] Qingdao Univ, Coll Med, Qingdao 266021, Shandong, Peoples R China
[2] Haici Hosp, Dept Gynecol & Obstet, Qingdao, Peoples R China
[3] Qingdao Univ, Coll Med, Affiliated Hosp 2, Qingdao 266021, Shandong, Peoples R China
来源：
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | 2013年 / 41卷 / 05期
关键词：
ethosome; gel; percutaneous penetration; simvastatin;
D O I：
10.3109/10731199.2012.743903
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
To prepare ethosome gel containing simvastatin ethosome and investigate the permeation behavior of simvastatin from ethosome gel. Cumulative permeation quantity in unit area and intradermal retention were the indicators to evaluate the effects of simvastatin in vitro percutaneous permeation behavior. Cumulative permeation quantity in unit area of simvastatin ethosome gel was significantly higher than other agents (P < 0.05), the intradermal retention of simvastatin ethosome gel, simvastatin gel containing 1%, and 3% menthol were significantly higher than simvastatin gel (P < 0.05). Ethosome gel could enhance the skin permeation and accumulation in a depot of simvastatin.
引用
收藏
页码：315 / 318
页数：4
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