Mesenchymal Stem Cells as Vectors for Lung Cancer Therapy

被引：26
|
作者：
Kolluri, Krishna K. [1 ]
Laurent, Geoff J. [2 ]
Janes, Sam M. [1 ]
机构：
[1] UCL, Lungs Living Res Ctr, London WC1E 6JJ, England
[2] Univ Western Australia, Ctr Cell Therapy & Regenerat Med, Perth, WA 6009, Australia
来源：
RESPIRATION | 2013年 / 85卷 / 06期
基金：
英国惠康基金;
关键词：
Apoptosis; Delivery vectors; Homing; Lung cancer; Mesenchymal stem cells; TRAIL; APOPTOSIS-INDUCING LIGAND; EXPRESSING INTERFERON-BETA; BONE-MARROW; STROMAL CELLS; PROGENITOR CELLS; IN-VITRO; TARGETED-DELIVERY; CARCINOMA CELLS; GROWTH-FACTOR; GENE-THERAPY;
D O I：
10.1159/000351284
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
Despite recent advances in treatment, lung cancer accounts for one third of all cancer-related deaths, underlining the need of development of new therapies. Mesenchymal stem cells (MSCs) possess the ability to specifically home into tumours and their metastases. This property of MSCs could be exploited for the delivery of various anti-tumour agents directly into tumours. However, MSCs are not simple delivery vehicles but cells with active physiological process. This review outlines various agents which can be delivered by MSCs with substantial emphasis on TRAIL (tumour necrosis factorrelated apoptosis-inducing ligand). Copyright (C) 2013 S. Karger AG, Basel
引用
收藏
页码：443 / 451
页数：9
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