Polyethylene glycol-bonded 1,8-diazabicyclo-[5.4.0] undec-7-ene (PEG-DBU) as a surfactant-combined base catalyst for the application of nucleosides as reagents in multi-component syntheses of 8-substituted pyrido[2,3-d]-pyrimidine-6-carbonitriles in water

被引：27

作者：

Shekouhy, Mohsen ^{[1
]}

Khalafi-Nezhad, Ali ^{[1
]}

机构：

[1] Shiraz Univ, Coll Sci, Dept Chem, Shiraz 71454, Iran

来源：

GREEN CHEMISTRY | 2015年 / 17卷 / 10期

关键词：

POLYMER-SUPPORTED BASES; ONE-POT SYNTHESIS; ORGANIC-SYNTHESIS; GREEN CHEMISTRY; PHASE SYNTHESIS; IONIC LIQUID; ACID; EFFICIENT; CONDENSATION; DERIVATIVES;

D O I：

10.1039/c5gc01448d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Polyethylene glycol-bonded 1,8-diazabicyclo[5.4.0]undec-7-ene (PEG-DBU) was prepared as a new surfactant-combined base catalyst and successfully applied in the syntheses of some novel 8-substituted pyrido[2,3-d]pyrimidine-6-carbonitriles via one-pot multi-component reactions in water using nucleosides (adenosine, guanosine and cytidine) as starting materials. The application of PEG-DBU used water as an available, green, and benign reaction medium instead of commonly used hazardous solvents (DMF, DMSO etc.) for the manipulation of nucleosides.

引用

页码：4815 / 4829

页数：15