Transdermal delivery of phenobarbital Preformulation studies

被引：2
|
作者：
Odri, S. [2 ]
Stupar, M. [3 ]
Eros, I. [1 ]
Antal, I. [2 ]
Klebovich, I. [2 ]
Szabo-Revesz, P. [1 ]
Csanyi, E. [1 ]
机构：
[1] Univ Szeged, Fac Pharm, Dept Pharmaceut Technol, H-6720 Szeged, Hungary
[2] Semmelweis Univ, Dept Pharmaceut, H-1092 Budapest, Hungary
[3] Univ Belgrade, Fac Pharm, Inst Pharmaceut Technol & Cosmetol, Belgrade 11000, Serbia
来源：
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY | 2008年 / 18卷 / 06期
关键词：
Physicochemical attributes; Partition coefficients; Solubility enhancing; Multicomponent solvents; Dielectric constant;
D O I：
10.1016/S1773-2247(08)50081-5
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The aim of this paper was to develop a phenobarbital solution suitable for trandermal administration, and preformulation studies were carried out in order to obtain the solution with the desired phenobarbital content. The preconditions necessary for the permeation processes through the skin and the lipophilicity of the active molecule were investigated and characterized quantitatively with its octanol/water partition coefficient. It was determined how the apparent partition coefficient values changed (logP(app)) in the function of changing the pH of the solvents. The amount of phenobarbital estimated for the successful treatment of grand mal epilepsy by the solution was ensured by using solvents of polar and semipolar character. An order based on the ability of the used solvens and cosolvents to increase the solubility of phenobarbital was established.
引用
收藏
页码：417 / 423
页数：7
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