Ailanthoidol Derivatives and their Anti-inflammatory Effects

被引：9
|
作者：
Lee, Na Li [1 ,2 ]
Lee, Jae Jun [1 ,2 ]
Kim, Jin-Kyung [3 ]
Jun, Jong-Gab [1 ,2 ]
机构：
[1] Hallym Univ, Dept Chem, Chunchon 200702, South Korea
[2] Hallym Univ, Inst Nat Med, Chunchon 200702, South Korea
[3] Catholic Univ Daegu, Coll Nat Sci, Dept Biomed Sci, Gyeungsan Si 700702, South Korea
来源：
BULLETIN OF THE KOREAN CHEMICAL SOCIETY | 2012年 / 33卷 / 06期
基金：
新加坡国家研究基金会;
关键词：
Ailanthoidol; 2-Arylbenzo[b]furan; Anti-inflammatory; Nitric oxide; Iodine-induced cyclization; LIGNANS;
D O I：
10.5012/bkcs.2012.33.6.1907
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Ailanthoidol showed a strong anti-inflammatory effect in a previous result. Ailanthoidol derivatives were prepared for the anti-inflammatory test using Sonogashira coupling, iodine induced cyclization and Wittig reaction. Anti-inflammatory effects of the prepared ailanthoidol derivatives were examined in lipopolysaccharide (LPS)-stimulated RAW 264-7 macrophages. The results showed that some ailanthoidol derivatives inhibited significantly the production of inflammatory mediator nitric oxide.
引用
收藏
页码：1907 / 1912
页数：6
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