A Gadolinium Complex Confined in Silica Nanoparticles as a Highly Efficient T1/T2 MRI Contrast Agent

被引：41

作者：

Wartenberg, Nicolas ^{[2
]}

Fries, Pascal ^{[1
]}

Raccurt, Olivier ^{[2
]}

Guillermo, Armel ^{[3
]}

Imbert, Daniel ^{[1
]}

Mazzanti, Marinella ^{[1
]}

机构：

[1] CEA Grenoble, Lab Reconnaissance Ionique & Chim Coordinat, UMR CEA UJF E 3, Serv Chim Inorgan & Biol,INAC, F-38054 Grenoble 9, France

[2] CEA Grenoble, DTNM LITEN DRT, Lab Chim & Secur NanoMat, F-38054 Grenoble 9, France

[3] CEA Grenoble, CEA CNRS UJF, UMR 5819,INAC, Grp Polymeres Conducteurs Ion,Serv Struct & Propr, F-38054 Grenoble 9, France

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2013年 / 19卷 / 22期

关键词：

contrast agents; gadolinium; lanthanides; luminescence; nanoparticles; HIGH-RELAXIVITY; THERANOSTIC APPLICATIONS; OPTIMIZATION; WATER; IONS;

D O I：

10.1002/chem.201300635

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Gd in silica: Noncovalent confinement of a monoaqua Gd chelate into biocompatible silica nanoparticles (NPs; see figure) by a sol-gel method affords a new example of nanosized contrast agents with very high per-Gd relaxivities. Such NPs provide a route to highly efficient multimodal contrast agents. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：6980 / 6983

页数：4

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