Effects of penicillin and erythromycin on adherence of invasive and noninvasive isolates of Streptococcus pyogenes to laminin

被引:1
|
作者
Smitran, Aleksandra [1 ]
Vukovic, Dragana [2 ]
Gajic, Ina [2 ]
Marinkovic, Jelena [3 ]
Ranin, Lazar [2 ]
机构
[1] Univ Banja Luka, Fac Med, Dept Microbiol & Immunol, Banja Luka, Republic Of Srp, Bosnia & Herceg
[2] Univ Belgrade, Fac Med, Inst Microbiol & Immunol, Belgrade, Serbia
[3] Univ Belgrade, Fac Med, Inst Med Stat & Informat, Belgrade, Serbia
来源
MEMORIAS DO INSTITUTO OSWALDO CRUZ | 2015年 / 110卷 / 05期
关键词
Streptococcus pyogenes; adherence; laminin; penicillin; erythromycin; GROUP-A STREPTOCOCCUS; VIRULENCE FACTOR; BINDING; INTERNALIZATION; FIBRONECTIN; PROTEIN;
D O I
10.1590/0074-02760150092
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
This study investigated the possible relationship between the invasiveness of group A Streptococcus (GAS) strains and their abilities to adhere to laminin and assessed the effects of subinhibitory concentrations of penicillin and erythromycin on the ability of GAS to adhere to laminin. The adherence of noninvasive and highly invasive isolates of GAS to laminin was significantly higher than the adherence displayed by isolates of low invasiveness. Antibiotic treatment caused significant reductions in adherence to laminin in all three groups of strains. Penicillin was more successful in reducing the adherence abilities of the tested GAS strains than erythromycin.
引用
收藏
页码:684 / 686
页数:3
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