CE-MS for proteomics: Advances in interface development and application

被引：65

作者：

Ramautar, Rawi ^{[1
]}

Heemskerk, Anthonius A. M. ^{[1
]}

Hensbergen, Paul J. ^{[1
]}

Deelder, Andre M. ^{[1
]}

Busnel, Jean-Marc ^{[1
,2
]}

Mayboroda, Oleg A. ^{[1
]}

机构：

[1] Leiden Univ, Med Ctr, Dept Parasitol, Biomol Mass Spectrometry Unit, NL-2300 RC Leiden, Netherlands

[2] Beckman Coulter, Brea, CA USA

来源：

JOURNAL OF PROTEOMICS | 2012年 / 75卷 / 13期

关键词：

Capillary electrophoresis; Electrospray ionization; MALDI; Sheath-liquid interface; Sheathless interface; Applications; ELECTROPHORESIS-MASS-SPECTROMETRY; ASSISTED-LASER-DESORPTION/IONIZATION; CAPILLARY-ZONE-ELECTROPHORESIS; RECOMBINANT-HUMAN-ERYTHROPOIETIN; MALDI-TOF/TOF MS; PEPTIDE ANALYSIS; CEREBROSPINAL-FLUID; QUANTITATIVE PROTEOMICS; ELECTROSPRAY INTERFACE; SEPARATION TECHNIQUES;

D O I：

10.1016/j.jprot.2012.04.050

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Capillary electrophoresis-mass spectrometry (CE-MS) has emerged as a powerful technique for the analysis of proteins and peptides. Over the past few years, significant progress has been made in the development of novel and more effective interfaces for hyphenating CE to MS. This review provides an overview of these new interfacing techniques for coupling CE to MS, covering the scientific literature from January 2007 to December 2011. The potential of these new CE-MS interfacing techniques is demonstrated within the field of (clinical) proteomics, more specifically "bottom-up" proteomics, by showing examples of the analysis of various biological samples. The relevant papers on CE-MS for proteomics are comprehensively summarized in tables, including, e.g. information on sample type and pretreatment, interfacing and MS detection mode. Finally, general conclusions and future perspectives are provided. (c) 2012 Elsevier B.V. All rights reserved.

引用

页码：3814 / 3828

页数：15

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