Degradation of human hemoglobin by organic C-nitroso compounds

被引：16

作者：

Yi, Jun ^{[1
]}

Ye, Guan ^{[1
]}

Thomas, Leonard M. ^{[1
]}

Richter-Addo, George B. ^{[1
]}

机构：

[1] Univ Oklahoma, Dept Chem & Biochem, Norman, OK 73019 USA

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 95期

基金：

美国国家科学基金会;

关键词：

X-RAY; COMPLEXES; TOXICITY; ANILINE; HEPATOCYTES; DITHIONITE; TRANSITION; LIGANDS; P450;

D O I：

10.1039/c3cc46174b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The crystal structure of the nitrosomethane adduct of human Hb shows N-binding of the MeNO ligands to heme Fe. The structure of the EtNO adduct reveals a surprising 4.9 angstrom heme slippage in the beta subunit, and explains the ability of C-nitroso compounds to degrade Hb removing it from circulation.

引用

页码：11179 / 11181

页数：3

共 50 条

[1] Degradation of human hemoglobin by organic C-nitroso compounds
Guan, Ye
Yi, Jun
Richter-Addo, George
[J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2014, 247
[2] C-NITROSO COMPOUNDS .X. C-NITROSO COMPOUNDS AS HYDROGEN BOND ACCEPTORS
ENGBERTS, JB
WAJER, TAJ
KRUK, C
DEBOER, TJ
[J]. RECUEIL DES TRAVAUX CHIMIQUES DES PAYS-BAS, 1969, 88 (07): : 795 - &
[3] Preparations of C-nitroso compounds
Gowenlock, BG
Richter-Addo, GB
[J]. CHEMICAL REVIEWS, 2004, 104 (07) : 3315 - 3340
[4] ANOMALOUS EMISSION OF C-NITROSO COMPOUNDS
BHUJLE, VV
[J]. SPECTROSCOPY LETTERS, 1977, 10 (07) : 587 - 591
[5] Magnetic anisotropy of C-nitroso compounds
Owens, Catherine
Blackstock, Silas
Kelley, Ariel
[J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2017, 253
[6] Computational thermochemistry of C-nitroso compounds
Novak, Igor
[J]. STRUCTURAL CHEMISTRY, 2016, 27 (05) : 1395 - 1401
[7] Computational thermochemistry of C-nitroso compounds
Igor Novak
[J]. Structural Chemistry, 2016, 27 : 1395 - 1401
[8] Dimerization of Aromatic C-Nitroso Compounds
Beaudoin, Daniel
Wuest, James D.
[J]. CHEMICAL REVIEWS, 2016, 116 (01) : 258 - 286
[9] C-NITROSO COMPOUNDS .14. OXIMES, NITROALKANES AND ALKYL NITRATES BY PHOTOLYSIS OF C-NITROSO COMPOUNDS AND ALKYL NITRITES
MACKOR, A
[J]. RECUEIL DES TRAVAUX CHIMIQUES DES PAYS-BAS, 1970, 89 (02): : 164 - &
[10] COORDINATION-COMPLEXES OF C-NITROSO COMPOUNDS - A C-13 NMR-STUDY OF SOME COMPLEXES OF PLATINUM WITH C-NITROSO COMPOUNDS
BOYD, ASF
BROWNE, G
GOWENLOCK, BG
MCKENNA, P
[J]. JOURNAL OF ORGANOMETALLIC CHEMISTRY, 1988, 345 (1-2) : 217 - 220

← 1 2 3 4 5 →