Formulation and evaluation of antiviral drug sofosbuvir fast dissolving tablets using natural super disintegrants

The main objective of this study to formulate of fast dissolving tablets of sofosbuvir, an antiviral drug used for hepatitis C virus. The direct compression method was employed for the formulation of sofosbuvir FDT and optimized for weight variation test, thickness, hardness, friability, wetting time, water absorption ratio, in-vitro disintegration test, and in-vitro dissolution studies, assay identification by using HPLC and stability studies. Master foimulation of F4, Sofosbuvir showed promising results compared to others foimulations and selected as the most suitable and best foimulation among them. It also has better efficacy, disintegration and dissolution time. F4 was fabricated with both super disintegrants like croscarmellose sodium and sodium starch glycolate that lead to its required features. This foimulation would be a good alternate for the management of viral diseases with better dissolution profile, stability and improved bioavailability for the patients.