Is Manganese (II) Pentaazamacrocyclic Superoxide Dismutase Mimic Beneficial for Human Sperm Mitochondria Function and Motility?

被引：33

作者：

Otasevic, Vesna ^{[1
]}

Korac, Aleksandra ^{[2
,3
]}

Vucetic, Milica ^{[1
]}

Macanovic, Biljana ^{[4
]}

Garalejic, Eliana ^{[4
]}

Ivanovic-Burmazovic, Ivana ^{[5
]}

Filipovic, Milos R. ^{[5
]}

Buzadzic, Biljana ^{[1
]}

Stancic, Ana ^{[1
]}

Jankovic, Aleksandra ^{[1
]}

Velickovic, Ksenija ^{[2
,3
]}

Golic, Igor ^{[2
,3
]}

Markelic, Milica ^{[2
,3
]}

Korac, Bato ^{[1
]}

机构：

[1] Univ Belgrade, Inst Biol Res Sinisa Stankovic, Dept Physiol, Belgrade 11060, Serbia

[2] Univ Belgrade, Fac Biol, Inst Zool, Belgrade 11060, Serbia

[3] Univ Belgrade, Ctr Electron Microscopy, Belgrade 11060, Serbia

[4] Clin Gynecol & Obstet Narodni Front, Belgrade, Serbia

[5] Univ Erlangen Nurnberg, Dept Chem & Pharm, D-91054 Erlangen, Germany

来源：

ANTIOXIDANTS & REDOX SIGNALING | 2013年 / 18卷 / 02期

关键词：

D O I：

10.1089/ars.2012.4684

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondria play an important role in sperm cell maturation and function. Here, we examined whether (and how) changes in sperm redox milieu affect the functional status of sperm mitochondria, that is, sperm functionality. Compared with the control, incubation in Tyrode's medium for 3 h, under noncapacitating conditions, decreased sperm motility, the amount of nitric oxide ((NO)-N-center dot), the number of MitoTracker (R) Green FM (MT-G) positive mitochondria, and the expression of complexes I and IV of the mitochondrial respiratory chain. In turn, superoxide dismutase (SOD) mimic (M40403) treatment restored/increased these parameters, as well as the expression of endothelial nitric oxide synthase, manganese SOD, and catalase. These data lead to the hypothesis that M40403 improves mitochondrial functional state and motility of spermatozoa, as well as (NO)-N-center dot might be involved in the observed effects of the mimic. Antioxid. Redox Signal. 18, 170-178.

引用

页码：170 / 178

页数：9

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