The role of necroptosis in cancer: A double-edged sword?

被引：87
|
作者：
Qin, Xia [1 ,2 ]
Ma, Dan [3 ]
Tan, Ye-xiong [1 ,2 ]
Wang, Hong-yang [1 ,2 ,4 ]
Cai, Zhenyu [1 ,2 ,4 ]
机构：
[1] Natl Ctr Liver Canc, Shanghai, Peoples R China
[2] Second Mil Med Univ, Eastern Hepatobiliary Surg Hosp, Int Cooperat Lab Signal Transduct, Shanghai, Peoples R China
[3] Third Mil Med Univ, Dept Gen Surg, Xinqiao Hosp, Chongqing, Peoples R China
[4] Fudan Univ, Shanghai Canc Ctr, Canc Inst, Shanghai, Peoples R China
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2019年 / 1871卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Necroptosis; Cancer; Metastasis; RIPK3; MLKL; MIXED LINEAGE KINASE; DOMAIN-LIKE PROTEIN; CELL-DEATH; PROGRAMMED NECROSIS; TUMOR-NECROSIS; RIPK1; ACTIVATION; GENOTOXIC STRESS; PROGNOSTIC VALUE; SMAC MIMETICS; APOPTOSIS;
D O I：
10.1016/j.bbcan.2019.01.006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Necroptosis is a programmed, caspasc-independent cell death that is morphologically similar to necrosis. Unlike apoptosis, necroptosis evokes inflammatory responses by releasing damage-associated molecular patterns. Recent studies suggest that tumor undergoes necroptosis in vivo and necroptosis has pro- or anti-tumoral effects in cancer development and progression. Furthermore, triggering necroptosis in tumor cells has been explored as a potential therapeutic strategy against cancer. Here, we will review the recent research progress of necroptosis in conferring anti- or pro-tumoral effects and its potential application in cancer therapy.
引用
收藏
页码：259 / 266
页数：8
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