Susceptibility to Alcoholic Pancreatitis but not Sporadic Pancreatitis Is Significantly Reduced by the IL23R R381Q Gene Variant

被引:1
|
作者
Barrie, Arthur [1 ]
Lamb, Janette [1 ]
Sandhu, Bimaljit [2 ]
LaRusch, Jessica [1 ]
Brand, Rhonda [1 ]
O'Connell, Michael [1 ]
Yadav, Dhiraj [1 ]
Whitcomb, David [1 ]
机构
[1] Univ Pittsburgh, Pittsburgh, PA USA
[2] Virginia Commonwealth Univ, Richmond, VA USA
来源
关键词
D O I
10.14309/00000434-201210001-00239
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
239
引用
收藏
页码:S103 / S103
页数:1
相关论文
共 50 条
  • [1] Functional Studies on the IBD Susceptibility Gene IL23R Implicate Reduced Receptor Function in the Protective Genetic Variant R381Q
    Pidasheva, Svetlana
    Trifari, Sara
    Phillips, Anne
    Hackney, Jason A.
    Ma, Yan
    Smith, Ashley
    Sohn, Sue J.
    Spits, Hergen
    Little, Randall D.
    Behrens, Timothy W.
    Honigberg, Lee
    Ghilardi, Nico
    Clark, Hilary F.
    PLOS ONE, 2011, 6 (10):
  • [2] The R381Q variant of the interleukin-23 receptor gene (IL23R) confers protection against psoriasis vulgaris
    Capon, F.
    Di Meglio, P.
    Allen, M.
    Baumber, L.
    Burden, D.
    Barker, J. N. W. N.
    Trembath, R. C.
    Nestle, F.
    BRITISH JOURNAL OF DERMATOLOGY, 2007, 156 (05) : 1099 - 1099
  • [3] IL23 Promotes Antimicrobial Pathways in Human Macrophages, Which Are Reduced With the IBD-Protective IL23R R381Q Variant
    Sun, Rui
    Abraham, Clara
    CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 2020, 10 (04): : 673 - 697
  • [4] IL23R (INTERLEUKIN 23 RECEPTOR) R381Q GENE VARIANT IMPACTS THE MICROBIAL COMPOSITION IN NON-IBD HEALTHY CONTROLS
    Zakrzewski, Martha
    Simms, Lisa A.
    Brown, Allison
    Appleyard, Mark
    Irwin, James
    Radford-Smith, Graham L.
    GASTROENTEROLOGY, 2018, 154 (06) : S639 - S639
  • [5] Human IL23R R381Q Genetic Variant Implicated in Crohn's Disease Pathogenesis is Hypomorphic Resulting in Reduced Function of the Receptor
    Clark, Hilary
    Pidasheva, Svetlana
    Trifari, Sara
    Hackney, Jason
    Ma, Yan
    Smith, Ashley
    Sohn, Sue
    Spits, Hergen
    Little, Randall
    Behrens, Timothy
    Honigberg, Lee
    Ghilardi, Nico
    GASTROENTEROLOGY, 2011, 140 (05) : S273 - S273
  • [6] IL23R (interleukin 23 receptor) R381Q gene variant affects the microbial phenotype in healthy controls without inflammatory bowel disease
    Radford-Smith, G. L.
    Zakrzewski, M.
    Brown, A.
    Appleyard, M.
    Simms, L. A.
    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2018, 33 : 135 - 135
  • [7] IL23R R381Q AND NOS3 E298D GENE POLYMORPHISMS IN ALOPECIA AREATA
    Alzolibani, A. A.
    Al Robaee, A.
    Al Shobaili, H.
    Bin Saif, G.
    Ali, A.
    Settin, A.
    DRUGS OF THE FUTURE, 2015, 40 (05) : 311 - 315
  • [8] Functional investigation of the psoriasis protective IL23R R381Q gene variant reveals impaired interleukin-23-induced Th17 response
    Di Meglio, P.
    Napolitano, L.
    Villanova, F.
    Di Cesare, A.
    Tosi, I.
    Laggner, U.
    Barberio, M. Terranova
    Mak, R. K.
    Peris, K.
    Spector, T. D.
    Smith, C. H.
    Barker, J. N. W. N.
    Nestle, F. O.
    BRITISH JOURNAL OF DERMATOLOGY, 2011, 165 (06) : E3 - E3
  • [9] IL23 induces IL23R recycling and amplifies innate receptor-induced signalling and cytokines in human macrophages, and the IBD-protective IL23R R381Q variant modulates these outcomes
    Sun, Rui
    Hedl, Matija
    Abraham, Clara
    GUT, 2020, 69 (02) : 264 - 273
  • [10] The IL23R R381Q Gene Variant Protects against Immune-Mediated Diseases by Impairing IL-23-Induced Th17 Effector Response in Humans
    Di Meglio, Paola
    Di Cesare, Antonella
    Laggner, Ute
    Chu, Chung-Ching
    Napolitano, Luca
    Villanova, Federica
    Tosi, Isabella
    Capon, Francesca
    Trembath, Richard C.
    Peris, Ketty
    Nestle, Frank O.
    PLOS ONE, 2011, 6 (02):