Activity of parthenolide at 5HT(2A) receptors

被引：24
|
作者：
Weber, JT [1 ]
OConnor, MF [1 ]
Hayataka, K [1 ]
Colson, N [1 ]
Medora, R [1 ]
Russo, EB [1 ]
Parker, KK [1 ]
机构：
[1] UNIV MONTANA,SCH PHARM,DEPT PHARMACEUT SCI,MISSOULA,MT 59812
来源：
JOURNAL OF NATURAL PRODUCTS | 1997年 / 60卷 / 06期
关键词：
D O I：
10.1021/np960644d
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Parthenolide displaces [H-3]ketanserin from 5HT(2A) receptors from rat and rabbit brain and cloned 5HT(2A) receptors. K-i's are in the 100-250 mu M range. These results suggest that parthenolide may be a low-affinity antagonist at 5HT receptors; it is unlikely that the entire mechanism of action can be explained by its modest 5HT(2A) receptor affinity.
引用
收藏
页码：651 / 653
页数：3
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