Convenient Preparation of Primary Amides via Activation of Carboxylic Acids with Ethyl Chloroformate and Triethylamine under Mild Conditions

被引：16

作者：

Noguchi, Takuya ^{[1
]}

Sekine, Masahiro ^{[1
]}

Yokoo, Yuki ^{[1
]}

Jung, Seunghee ^{[1
]}

Imai, Nobuyuki ^{[1
]}

机构：

[1] Chiba Inst Sci, Fac Pharm, Choshi, Chiba 2880025, Japan

来源：

CHEMISTRY LETTERS | 2013年 / 42卷 / 06期

关键词：

PEPTIDE-SYNTHESIS; AMINO-ACIDS;

D O I：

10.1246/cl.130096

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Primary amides were easily prepared in 22-99% yields from the corresponding carboxylic acids 1 or 5 with NH4Cl via activation with ClCO2Et and Et3N. The enantiomers of the corresponding primary amides of Cbz-, Boc-, or Fmoc-alpha-amino acids can be separated by using a chiral column.

引用

页码：580 / 582

页数：3

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