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Albert Hofmann's pioneering work on ergot alkaloids and its impact on the search of novel drugs at Sandoz, a predecessor company of novartis - Dedicated to Dr. Albert Hofmann on the occasion of his 100th birthday
被引：7
|作者：
Giger, RKA
Engel, G
机构：
[1] Novartis Pharma AG, NIBR Global Discovery Chem, Lead Synth & Chemogenet, CH-4002 Basel, Switzerland
[2] Novartis Pharma AG, Project Management, Exploratory Dev, CH-4002 Basel, Switzerland
来源：
关键词：
aminocyclole;
bromocriptine Parlodel (R);
dihydroergotamine Dihydergot (R);
dihydro ergot peptide alkaloids;
ergobasin/ergometrin;
ergocornine;
ergocristine;
alpha- and beta-ergocryptine;
ergolene;
ergoline;
ergoloid mesylate Hydergine (R);
ergotamine Gynergen (R);
ergotoxine;
lisuride;
lysergic acid diethylamide LSD;
methylergometrine Methergine (R);
methysergide Deseril (R);
paspalic acid;
pindolol Visken (R);
psilocybin;
serotonin;
tegaserod Zelmac (R)/Zelnorm (R);
tropisetron Navoban (R);
D O I：
10.2533/000942906777675164
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The scientific research on ergot alkaloids is fundamentally related to the work of Dr. Albert Hofmann, who was able to produce, from 1935 onwards, a number of novel and valuable drugs, some of which are still in use today. The complex chemical structures of ergot peptide alkaloids and their pluripotent pharmacological activity were a great challenge for Dr. Hofmann and his associates who sought to unravel the secrets of the ergot peptide alkaloids; a source of inspiration for the design of novel, selective and valuable medicines.
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页码：83 / 87
页数：5
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