Particle size control of poly(DL-lactide-co-glycolide) nanospheres for sterile applications

被引：33

作者：

Tsukada, Yusuke ^{[1
]}

Hara, Kaori ^{[1
]}

Bando, Yohei ^{[1
]}

Huang, C. C. ^{[2
]}

Kousaka, Yasuo ^{[1
]}

Kawashima, Yoshiaki ^{[3
]}

Morishita, Ryuichi ^{[4
]}

Tsujimoto, Hiroyuki ^{[1
]}

机构：

[1] Hosokawa Powder Technol Res Inst, Hirakata, Osaka 5731132, Japan

[2] Hosokawa Micron Powder Syst, Summit, NJ 07901 USA

[3] Aichi Gakuin Univ, Chikusa Ku, Aichi 4648650, Japan

[4] Osaka Univ, Grad Sch Med, Div Gene Therapy Sci, Suita, Osaka 5650871, Japan

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2009年 / 370卷 / 1-2期

关键词：

PLGA nanospheres; ESD method; Drug delivery system; Pressure filtration; Sterilization; Particle size; SOLVENT DIFFUSION METHOD; LEUPRORELIN ACETATE; NANOPARTICLES; POLYMERS; DESIGN; PLGA;

D O I：

10.1016/j.ijpharm.2008.11.019

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Parameters affecting the particle sizes of poly(DL-lactide-co-glycolide) (PLGA) nanospheres produced by the Emulsion Solvent Diffusion (ESD) method were evaluated in this study, so that suitable PLGA nanospheres could be prepared to pass through a membrane filter with 0.2 mu m pore size and used as a sterile product. Experimental results demonstrated that the particle sizes of PLGA nanospheres could be reduced by the following efforts. (1) Increase stirring rate of poor solvent. (2) Decrease feed rate of good solvent. (3) Increase poor solvent ratio. (4) Increase the temperature of poor solvent. (5) Decrease polyvinyl alcohol concentration in poor solvent. (6) Increase ethanol concentration in good solvent. (7) Decrease PLGA concentration in good solvent. After optimization, PLGA nanospheres with a mean particle size of 102-163 nm and the 100-98% of filtration fraction could be produced and passed the bacteria challenge tests. This study found PLGA nanospheres can be efficiently prepared as a sterile product. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：196 / 201

页数：6

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