Advanced Glycation End Products in Pregnancies Complicated with Diabetes Mellitus or Preeclampsia

被引：27
|
作者：
Harsem, Nina K. [1 ]
Braekke, Kristin [2 ]
Torjussen, Tale [2 ]
Hanssen, Kristian [4 ]
Staff, Anne Cathrine [1 ,3 ]
机构：
[1] Ullevaal Univ Hosp, Dept Obstet & Gynecol, Oslo, Norway
[2] Ullevaal Univ Hosp, Dept Pediat Intens Care, Oslo, Norway
[3] Univ Oslo, Ulleval Univ Hosp, Fac Med, N-0316 Oslo, Norway
[4] Aker Univ Hosp, Dept Med, Oslo, Norway
来源：
HYPERTENSION IN PREGNANCY | 2008年 / 27卷 / 04期
关键词：
Diabetes mellitus; Pregnancy; Preeclampsia; AGE; Oxidative stress;
D O I：
10.1080/10641950802000968
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Objective: Preeclampsia (PE) and diabetes mellitus (DM) are associated with oxidative stress. DM is complicated with formation of advanced glycation end products (AGEs), which are associated with oxidative stress. We hypothesized that elevated serum AGE would be found in pregnancies complicated by PE or DM. Methods: Circulating AGEs, 8-isoprostane, vitamin E, and antioxidant capacity were analyzed from study patients. Results: Serum AGE was elevated both in patients with type 1 DM and gestational DM, but not in PE, compared with controls. 8-isoprostane was elevated in patients with type 1 DM and PE compared with controls. Conclusion: AGEs and 8-isoprostane are not elevated in parallel in pregnancies complicated with PE or DM, suggesting biological heterogeneity.
引用
收藏
页码：374 / 386
页数：13
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