The effect of sodium valproate on the biochemical parameters of reproductive function in male albino Wistar rats

被引：0
|
作者：
Vijay, P. [2 ]
Yeshwanth, R. [3 ]
Bairy, K. L. [1 ]
机构：
[1] Kasturba Med Coll & Hosp, Dept Pharmacol, Manipal, Karnataka, India
[2] Maleka Manipal Med Coll, Dept Anat, Manipal, Karnataka, India
[3] Maleka Manipal Med Coll, Dept Pharmacol, Manipal, Karnataka, India
来源：
INDIAN JOURNAL OF PHARMACOLOGY | 2008年 / 40卷 / 06期
关键词：
Lactate dehydrogenase; sodium valproate; testosterone;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Objective: To assess the effects of sodium valproate on intratesticular testosterone and lactic dehydrogenase level in rats. Methods: Male Wistar rats (12 weeks old) were treated with sodium valproate and sacrificed at the end of the 2 (nd) , 4 (th) , 5 (th) , 7 (th) , 10 (th) and 15 (th) week, after the last exposure to sodium valproate. The testes were removed, weighed and processed for biochemical analysis. Results: The intratesticular testosterone level was significantly (P 0.001) reduced in 200 mg/kg and 400 mg/kg treated rats. The intratesticular lactate dehydrogenase (LDH) level was significantly (P 0.001) increased by valproate in a time dependent manner. Conclusion: Valproate causes reversible change in intratesticular testosterone and LDH level.
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页码：248 / 250
页数：3
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