Influence of the non-competitive NMDA receptor antagonist MK-801 on 2-deoxy-D-glucose-induced hyperphagia in rats

被引：3
|
作者：
Sugimoto, Y [1 ]
Yamada, J [1 ]
Yoshikawa, T [1 ]
机构：
[1] Kobe Pharmaceut Univ, Dept Pharmacol, Higashinada Ku, Kobe, Hyogo 6588558, Japan
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1999年 / 378卷 / 02期
关键词：
2-deoxy-D-glucose; nitric oxide (NO); MK-801; NMDA receptor; N-G-nitro-L-arginine methyl ester; food intake;
D O I：
10.1016/S0014-2999(99)00472-0
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effects of the glutamate N-methyl-D-aspartate (NMDA) receptor antagonist (5R,10S)-(+)-5-methyl-10,11-dihydro-5H-dibenzo[ a,d]cyclo-hepten-5, 10-imine (MK-801) on 2-deoxy-D-glucose-induced hyperphagia were investigated in rats. MK-801 significantly increased 2-deoxy-D-glucose-elicited eating. The facilitating effects of MK-801 on 2-deoxy-D-glucose-elicited feeding were not affected by coadministration of a nitric oxide (NO) precursor, L-arginine. Because NO synthase inhibitors inhibit 2-deoxy-D-glucose-induced hyperphagia and activation of the NMDA receptor leads to NO formation, our results suggest that blockade of the NMDA receptor increases 2-deoxy-D-glucose-induced hyperphagia, which is unrelated to inhibition of NO, and that NMDA receptors may play a role in satiety. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：149 / 152
页数：4
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