Interleukin-1 receptor antagonist (IL-1ra) modulates endothelial cell proliferation

被引：16
|
作者：
Dewberry, Rachael M. [1 ]
King, Andrea R. [1 ]
Crossman, David C. [1 ]
Francis, Sheila E. [1 ]
机构：
[1] Univ Sheffield, Cardiovasc Res Unit, Sch Med & Biomed Sci, Royal Hallamshire Hosp, Sheffield S10 2RX, S Yorkshire, England
来源：
FEBS LETTERS | 2008年 / 582卷 / 06期
关键词：
endothelial cell; IL-1ra; proliferation;
D O I：
10.1016/j.febslet.2008.02.021
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Endothelial cell (EC) lifespan controlled by the IL-1 family of cytokines is an important determinant of susceptibility to artery wall disease. Here we show that EC lacking intracellular interleukin-1 receptor antagonist (IL-1ra) have a reduced lifespan compared to controls. Over expression of IL-1ra enhanced proliferation via cyclin dependent kinase 2 activity and retinoblastoma protein phosphorylation. This was not seen in EC lacking IL-1 receptor 1 (IL-1 signalling ability), nor apparent using other stimuli e.g. TNF alpha. These data suggest that IL-1ra has a specific and receptor-dependent function to control the growth and lifespan of EC. (C) 2008 Federation of European Biochemical Societies. Published by Else-tier B.V. All rights reserved.
引用
收藏
页码：886 / 890
页数：5
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