Predictive Biomarkers in Breast Cancer: Their Value in Neoadjuvant Chemotherapy

被引：21
|
作者：
Fuksa, L. [2 ]
Micuda, S. [1 ]
Grim, J. [3 ]
Ryska, A. [4 ]
Hornychova, H. [4 ]
机构：
[1] Charles Univ Prague, Fac Med Hradec Kralove, Dept Pharmacol, Hradec Kralove 50038, Czech Republic
[2] Charles Univ Prague, Fac Pharm, Dept Social & Clin Pharm, Hradec Kralove 50038, Czech Republic
[3] Charles Univ Prague, Fac Med Hradec Kralove, Dept Oncol, Hradec Kralove 50038, Czech Republic
[4] Charles Univ Prague, Sch Med, Dept Pathol, Hradec Kralove, Czech Republic
来源：
CANCER INVESTIGATION | 2012年 / 30卷 / 09期
关键词：
Breast Cancers; Chemotherapy; Prognosis and response predictions; PATHOLOGICAL COMPLETE RESPONSE; ESTROGEN-RECEPTOR STATUS; TOPOISOMERASE-II-ALPHA; DISEASE-FREE SURVIVAL; INTERNATIONAL EXPERT CONSENSUS; TUMOR-INFILTRATING LYMPHOCYTES; ADJUVANT CHEMOTHERAPY; PREOPERATIVE CHEMOTHERAPY; DOXORUBICIN DISPOSITION; PROGNOSTIC-SIGNIFICANCE;
D O I：
10.3109/07357907.2012.725441
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Neoadjuvant chemotherapy (NCT) of breast cancer enabled improved outcomes especially in patients with advanced and inflammatory diseases. Biological heterogeneity of these tumors, however, requires better molecular characterization of the malignant tissue with consequent individualization in the selection of appropriate agents. To date, numerous molecular markers have been identified, and some of them (e. g., measurement of hormonal or growth factors receptors) are already routinely used for breast cancer classification before NCT. In the present article, we summarize current knowledge about established as well as promising biomarkers which have demonstrated prognostic or predictive value in NCT of breast cancer.
引用
收藏
页码：663 / 678
页数：16
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