Type I Interferon Signature in Systemic Lupus Erythematosus

被引：1

作者：

Bezalel, Shira

Guri, Keren Mahlab

Elbirt, Daniel

Asher, Ilan

Sthoeger, Zev Moshe ^{[1
,2
,3
,4
]}

机构：

[1] Kaplan Med Ctr, Dept Med B, IL-76100 Rehovot, Israel

[2] Kaplan Med Ctr, Dept Clin Immunol, IL-76100 Rehovot, Israel

[3] Kaplan Med Ctr, Dept Allergy, IL-76100 Rehovot, Israel

[4] Kaplan Med Ctr, AIDS Ctr, IL-76100 Rehovot, Israel

来源：

ISRAEL MEDICAL ASSOCIATION JOURNAL | 2014年 / 16卷 / 04期

关键词：

interferon-alpha (IFN alpha); interferon signature; systemic lupus erythematosus (SLE); PLASMACYTOID DENDRITIC CELLS; DISEASE-ACTIVITY; ASSOCIATION; EXPRESSION; RISK; IFN;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Type I interferons (IFN) are primarily regarded as an inhibitor of viral replication. However, type I IFN, mainly IFN alpha, plays a Major role in activation of both the innate and adaptive immune systems. Systemic lupus erythematosus (SLE) is a chronic, multi-systemic, inflammatory autoimmune disease With undefined etiology. SLE is Characterized by dysregulation of both the innate and the adaptive immune systems. An increased expression of type I IFN-regulated genes, termed IFN signature, has been reported in patients with SLE. We review here the role of IFNa in the pathogenesis and course of SLE and the possible role of IFNa inhibition as a navel treatment for lupus patients.

引用

页码：246 / 249

页数：4

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