Regulation of PPARγ function by TNF-α

被引：141

作者：

Ye, Jianping ^{[1
]}

机构：

[1] Louisiana State Univ, Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2008年 / 374卷 / 03期

关键词：

TNF-alpha; PPAR gamma; nuclear corepressor;

D O I：

10.1016/j.bbrc.2008.07.068

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The nuclear receptor PPAR gamma is a lipid sensor that regulates lipid metabolism through gene transcription. Inhibition of PPAR gamma activity by TNF-alpha is involved in pathogenesis of insulin resistance, atherosclerosis, inflammation, and cancer cachexia. PPAR gamma activity is regulated by TNF-alpha at pre-translational and post-translational levels. Activation of serine kinases including IKK, ERK, JNK, and p38 may be involved in the TNF-regulation of PPAR gamma. Of the four kinases, IKK is a dominant signaling molecule in the TNF-regulation of PPAR gamma. IKK acts through at least two mechanisms: inhibition of PPAR gamma expression and activation of PPAR gamma corepressor. In this review article, literature is reviewed with a focus on the mechanisms of PPAR gamma inhibition by TNF-alpha. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：405 / 408

页数：4

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